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Hua Jiang Selected Research

Chimeric Antigen Receptors

5/2024GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma.
11/2023CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer.
1/2023Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death.
12/2022Subsequent anti-myeloma therapy after maturation antigen (BCMA) chimeric antigen receptor (CAR)-T cell (HDS269B) treatment in patients with relapsed/refractory multiple myeloma.
11/2022Pre-clinical efficacy of CD20-targeted chimeric antigen receptor T cells for non-Hodgkin's lymphoma.
6/2022Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors.
1/2022CAR-T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance status.
1/2021Anti-CLL1 Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia.
1/2021Current Challenges and Strategies for Chimeric Antigen Receptor-T-Cell Therapy for Solid Tumors.
10/2020Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned Lymphodepletion.
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Hua Jiang Research Topics

Disease

184Neoplasms (Cancer)
05/2024 - 01/2005
35Inflammation (Inflammations)
04/2024 - 06/2006
33Multiple Myeloma
10/2023 - 06/2005
31Infections
01/2024 - 03/2004
24Hepatocellular Carcinoma (Hepatoma)
06/2024 - 06/2009
20Breast Neoplasms (Breast Cancer)
04/2024 - 06/2012
20Neoplasm Metastasis (Metastasis)
01/2023 - 05/2011
18Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2023 - 08/2005
17Pancreatic Neoplasms (Pancreatic Cancer)
10/2022 - 01/2004
15Pain (Aches)
01/2024 - 02/2012
14Carcinogenesis
12/2023 - 03/2007
13Type 2 Diabetes Mellitus (MODY)
09/2021 - 06/2012
12Critical Illness (Critically Ill)
01/2024 - 12/2002
12Graft vs Host Disease (Graft-Versus-Host Disease)
10/2023 - 12/2008
12Wounds and Injuries (Trauma)
05/2023 - 12/2002
12Homocystinuria
01/2021 - 10/2010
11Body Weight (Weight, Body)
03/2024 - 09/2014
11Hemorrhage
09/2023 - 04/2010
10Insulin Resistance
01/2024 - 01/2013
10Carcinoma (Carcinomatosis)
12/2023 - 01/2016
10Retinoblastoma (Glioblastoma, Retinal)
12/2023 - 01/2005
10Residual Neoplasm
12/2023 - 06/2008
10Leukemia
11/2023 - 03/2010
10Fibrosis (Cirrhosis)
11/2023 - 11/2006
10Lung Neoplasms (Lung Cancer)
01/2023 - 03/2010
9Hematologic Neoplasms (Hematological Malignancy)
05/2024 - 10/2012
9Sepsis (Septicemia)
01/2024 - 07/2014
9Prostatic Neoplasms (Prostate Cancer)
01/2023 - 10/2015
9Hypoxia (Hypoxemia)
11/2022 - 01/2013
8Colorectal Neoplasms (Colorectal Cancer)
09/2023 - 03/2014
8Glioblastoma (Glioblastoma Multiforme)
02/2022 - 11/2013
8Stomach Neoplasms (Stomach Cancer)
01/2022 - 04/2006
8Shock
12/2021 - 01/2006
8Ovarian Neoplasms (Ovarian Cancer)
04/2021 - 10/2011
8Atherosclerosis
05/2020 - 09/2005
8Acute Kidney Injury (Acute Renal Failure)
01/2020 - 08/2011
7Melanoma (Melanoma, Malignant)
01/2024 - 06/2010
7Adenocarcinoma
12/2023 - 06/2016
7Cicatrix (Scar)
11/2023 - 01/2004
7Uterine Cervical Neoplasms (Cancer of the Cervix)
10/2023 - 01/2016
7Pneumonia (Pneumonitis)
09/2023 - 12/2008
7Intervertebral Disc Degeneration
04/2023 - 01/2017
7Cardiovascular Diseases (Cardiovascular Disease)
01/2023 - 03/2012
7Ovarian Epithelial Carcinoma
03/2022 - 11/2013
7Disease Progression
01/2022 - 09/2009
7Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 03/2010
6COVID-19
07/2024 - 01/2020
6Postoperative Pain
01/2024 - 08/2010
6Burns
01/2024 - 12/2002
6Thrombosis (Thrombus)
11/2023 - 03/2004
6beta-Thalassemia (Cooley's Anemia)
10/2023 - 01/2015
6Adenocarcinoma of Lung
01/2023 - 01/2017

Drug/Important Bio-Agent (IBA)

64Proteins (Proteins, Gene)FDA Link
03/2024 - 01/2004
38Biomarkers (Surrogate Marker)IBA
12/2023 - 03/2010
25Chimeric Antigen ReceptorsIBA
05/2024 - 03/2014
24ErbB Receptors (EGF Receptor)IBA
11/2022 - 01/2009
24Messenger RNA (mRNA)IBA
12/2020 - 04/2003
23CytokinesIBA
07/2023 - 06/2006
20Long Noncoding RNAIBA
01/2023 - 12/2016
16Interleukin-6 (Interleukin 6)IBA
07/2023 - 05/2007
16MicroRNAs (MicroRNA)IBA
01/2023 - 12/2013
16Therapeutic UsesIBA
01/2022 - 06/2006
16epidermal growth factor receptor VIIIIBA
06/2021 - 06/2009
13AntigensIBA
05/2024 - 04/2017
12LipidsIBA
09/2023 - 07/2005
11Monoclonal AntibodiesIBA
07/2023 - 01/2012
9Hemoglobins (Hemoglobin)IBA
02/2024 - 03/2012
9Indicators and Reagents (Reagents)IBA
10/2022 - 11/2006
8Glucose (Dextrose)FDA LinkGeneric
05/2024 - 05/2014
8Dexamethasone (Maxidex)FDA LinkGeneric
10/2023 - 11/2010
8Thalidomide (Thalomid)FDA Link
10/2023 - 09/2007
8RNA (Ribonucleic Acid)IBA
09/2023 - 01/2021
8Circular RNAIBA
01/2023 - 01/2018
8Small Interfering RNA (siRNA)IBA
03/2022 - 11/2006
8Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2019 - 01/2004
7Transcription Factors (Transcription Factor)IBA
11/2023 - 03/2006
7CollagenIBA
03/2022 - 11/2006
7Insulin (Novolin)FDA Link
01/2021 - 12/2011
7CystathionineIBA
01/2019 - 03/2012
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2024 - 08/2005
6EnzymesIBA
03/2024 - 03/2008
6CholesterolIBA
09/2023 - 09/2009
6AcidsIBA
01/2023 - 04/2005
6Interleukin-12 (IL 12)IBA
10/2022 - 07/2007
6GlypicansIBA
06/2022 - 12/2014
6LigandsIBA
01/2022 - 02/2013
6Cystathionine beta-Synthase (Serine Sulfhydrase)IBA
01/2021 - 10/2010

Therapy/Procedure

118Therapeutics
04/2024 - 01/2004
38Drug Therapy (Chemotherapy)
09/2023 - 08/2006
20Transplantation
04/2024 - 08/2007
20Immunotherapy
04/2024 - 01/2013
18Hematopoietic Stem Cell Transplantation
01/2024 - 12/2008
13Radiotherapy
03/2024 - 05/2010
9Length of Stay
01/2024 - 10/2009
7Ligation
11/2023 - 09/2006
7Cell Transplantation
09/2023 - 01/2015
6Nutritional Support (Artificial Feeding)
03/2024 - 01/2019
6Stents
11/2023 - 09/2006
6Hysterectomy
08/2023 - 01/2016
6Resuscitation
01/2023 - 09/2006